Bad CLIA Kit for Mouse(Mus musculus) | EIAab.comBad CLIA Kit for Mouse(Mus musculus)

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Bad (Gene name),

Bcl2 antagonist of cell death (Protein name ), BAD_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Bad(Bbc6);

Protein name:

Bcl2 antagonist of cell death(BAD);

Alternative:

Bcl-xL/Bcl-2-associated death promoter;Bcl-2-binding component 6;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Forms heterodimers with the anti-apoptotic proteins, Bcl-X(L), Bcl-2 and Bcl-W. Also binds protein S100A10 (By similarity). The Ser-112/Ser-136 phosphorylated form binds 14-3-3 proteins. Interacts with PIM3.

Function:

Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.

Subcellular Location:

Mitochondrion outer membrane Cytoplasm Upon phosphorylation, locates to the cytoplasm.

Protein Attributes:

Sequence length:

204

Sequence:

50:

100:

150:

200:

204:

TPSQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:12015

Pfam:

PF10514

String:

Q61337

UniGene:

Mm.4387

SMR:

Q61337

Uniprot:

Q61337

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ELISA Kit for Mouse BAD

Cat.:

E15040h

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96T

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ELISA Kit for Mouse BAD

MSDS:

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ELISA Kit for Mouse BAD

Cat.:

E15040m

Price:

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Manual:

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MSDS:

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Packing:

96T

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CLIA Kit for Mouse BAD

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CLIA Kit for Mouse BAD

MSDS:

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CLIA Kit for Mouse BAD

Cat.:

U15040h

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Packing:

96T

Polyclonal Antibody for Mouse BAD

Monoclonal Antibody for Mouse BAD

Protein for Mouse BAD

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death."
Yang E. , Zha J. , Jockel J. , Boise L.H. , Thompson C.B. , Korsmeyer S.J.
Cell80:285-291(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
tissue: Thymus.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: NMRI.
tissue: Mammary gland.
3.

"Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt."
Del Peso L. , Gonzalez-Garcia M. , Page C. , Herrera R. , Nunez G.
Science278:687-689(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-112 AND SER-136;MUTAGENESIS OF SER-112 AND SER-136
4.

"Rsk1 mediates a MEK-MAP kinase cell survival signal."
Shimamura A. , Ballif B.A. , Richards S.A. , Blenis J.
Curr. Biol.10:127-135(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-112 AND SER-136
5.

"14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation."
Datta S.R. , Katsov A. , Hu L. , Petros A. , Fesik S.W. , Yaffe M.B. , Greenberg M.E.
Mol. Cell6:41-51(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF SERINE RESIDUES
6.

"p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis."
Schurmann A. , Mooney A.F. , Sanders L.C. , Sells M.A. , Wang H.G. , Reed J.C. , Bokoch G.M.
Mol. Cell. Biol.20:453-461(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-112 AND SER-136
7.

"p21-activated protein kinase gamma-PAK suppresses programmed cell death of BALB3T3 fibroblasts."
Jakobi R. , Moertl E. , Koeppel M.A.
J. Biol. Chem.276:16624-16634(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-112
8.

"Protein kinase C-theta mediates a selective T cell survival signal via phosphorylation of BAD."
Villalba M. , Bushway P. , Altman A.
J. Immunol.166:5955-5963(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-136
9.

"p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD."
Harada H. , Andersen J.S. , Mann M. , Terada N. , Korsmeyer S.J.
Proc. Natl. Acad. Sci. U.S.A.98:9666-9670(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-136
10.

"Identification of a novel phosphorylation site, Ser-170, as a regulator of bad pro-apoptotic activity."
Dramsi S. , Scheid M.P. , Maiti A. , Hojabrpour P. , Chen X. , Schubert K. , Goodlett D.R. , Aebersold R. , Duronio V.
J. Biol. Chem.277:6399-6405(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-155 AND SER-170;MUTAGENESIS OF SER-112; SER-155 AND SER-170;IDENTIFICATION BY MASS SPECTROMETRY
11.

"The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death."
Yan B. , Zemskova M. , Holder S. , Chin V. , Kraft A. , Koskinen P.J. , Lilly M.
J. Biol. Chem.278:45358-45367(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-112 BY PIM2
12.

"p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association."
Jin S. , Zhuo Y. , Guo W. , Field J.
J. Biol. Chem.280:24698-24705(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-112 BY RAF1
13.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.

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